Solubility and Melting Properties of Salicylic Acid

2006/07/11 by Fredrik L. Nordström, Åke C. Rasmuson · 11 citations
Chemistry · Materials Science · #Analytical Chemistry and Chromatography #Crystallization and Solubility Studies #Chemical Thermodynamics and Molecular Structure

paper · doi:10.1021/je060134d

Abstract

The solubility of salicylic acid has been investigated in methanol, acetonitrile, acetic acid, acetone, water, and ethyl acetate from (10 to 50) °C. No new polymorphs or solvates of salicylic acid were found. The melting properties of salicylic acid were determined by differential scanning calorimetry. A correlation was observed between the solubility and the van't Hoff enthalpy of solution. A higher solubility was related to a lower van't Hoff enthalpy of solution. Water differed from the organic solvents in terms of solubility and its correlation to the van't Hoff enthalpy of solution. In addition, the morphology of salicylic acid crystals recrystallized from water differed from the other solvents.

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