Solubilities of Salicylic Acid in Pure Solvents and Binary Mixtures Containing Cosolvent

2008/10/11 by Hiroyuki Matsuda, Kenta Kaburagi, Sho Matsumoto +3 · 6 citations
Materials Science · Chemistry · Chemical Engineering · #Crystallization and Solubility Studies #Analytical Chemistry and Chromatography #Chemical and Physical Properties in Aqueous Solutions

paper · doi:10.1021/je800475d

Abstract

The solubility of salicylic acid in water, methanol, ethanol, ethyl acetate, polyethylene glycol (PEG) 300, and 1,4-dioxane and in various binary solvent mixtures, methanol + water, ethanol + water, ethanol + ethyl acetate, PEG 300 + water, and 1,4-dioxane + water, were determined using high-performance liquid chromatography (HPLC). The experimental solubility data were correlated by two local composition models: modified Wilson and nonrandom two-liquid (NRTL) 1.

Citations

• Solubility of Salicylic Acid in Water, Ethanol, Carbon Tetrachloride, Ethyl Acetate, and Xylene
• Solubility and Melting Properties of Salicylic Acid

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• Solubility of 2-Hydroxybenzoic Acid in Water, 1-Propanol, 2-Propanol, and 2-Propanone at (298.2 to 338.2) K and Their Aqueous Binary Mixtures at 298.2 K
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• Investigation of the solubility and thermodynamics of salicylic acid in 2-propanol and ethylene glycol/propylene glycol binary solvent mixtures at (293.15 to 313.15) K. [europepmc]
• Evaluating the Effectiveness of Reference Solvent Solubility Calculations for Binary Mixtures Based on Pure Solvent Solubility: The Case of Phenolic Acids. [europepmc]
• When Does Machine Learning Add Value over Theory? Predicting API Solubility in Binary Mixtures with COSMO-RS and DOOIT2 Across Diverse and Homogeneous Systems. [europepmc]

Related

• Solubility of Salicylic Acid in Water, Ethanol, Carbon Tetrachloride, Ethyl Acetate, and Xylene
• Solubility and Melting Properties of Salicylic Acid
• Solubility of Salicylic Acid, Salicylamide, and Fenofibrate in Organic Solvents at Low Temperatures
• Solubility of 2-Hydroxybenzoic Acid in Water, 1-Propanol, 2-Propanol, and 2-Propanone at (298.2 to 338.2) K and Their Aqueous Binary Mixtures at 298.2 K
• Solubility of 2-Hydroxybenzoic Acid in Select Organic Solvents at 298.15 K