2017/10/10 by Thiruvallur R. Gowrishankar, Gowrishankar, Thiruvallur R., Julie Stern +3
Biochemistry, Genetics and Molecular Biology · Engineering · Medicine · #Biological Physics (physics.bio-ph) #Electrostatic Discharge in Electronics #FOS: Physical sciences #Microbial Inactivation Methods #Plasma Applications and Diagnostics #Pulsed Power Technology Applications
paper · pdf · doi:10.48550/arxiv.1710.03650
openalex publication_date 2017/10/10 · openalex created_date 2022/09/03 · openalex updated_date 2026/07/28
Standard model of electropration (EP) has long emphasized a single pore\nlifetime to explain post-pulse transport across cell membranes. However, pore\nlifetimes estimated from molecular dynamics (MD) models and and those measured\nfrom experimental data differ by several orders of magnitude. We hypothesize\nthat a broad distribution of lifetimes may describe the post-pulse behavior.\nHere, we show that pore distribution, number and size of pores, show\ninteresting behavior in different ranges of pore lifetimes. Interestingly, for\nlarge electric fields (greater than 1 kV/cm) and short pore lifetimes\n(approximately 100 ns), an significant loss in pore number occurs during the\npulse. Given the large number of EP applications that apply such fields, this\nphenomenon may be crucial to post-pulse response of cell membrane to such\nfields.\n