2006/10/27 by Donna O. Lowe, Simon R. Knowles, Elizabeth Weber +2 · 1 citation
Medicine · #Adverse effect #Anesthesia #Antiseptic #Buttocks #Chemical burn #Chemotherapy-related skin toxicity #Complication #Dermatology #Drug-Induced Adverse Reactions #Internal medicine #Iodine #Itching #Medicine #Poisoning and overdose treatments #Surgery
paper · doi:10.1592/phco.26.11.1641
openalex publication_date 2006/10/27 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Burns are a rare but potentially serious complication of povidone-iodine use. This rare adverse drug reaction developed in a 38-year-old woman who underwent laparoscopic right ovarian cystectomy and endometrial ablation as a day procedure involving application of the topical antiseptic 10% povidone-iodine solution. Two days later, the patient was admitted to the hospital with burning, pain, itching, marked redness, and blistering extending from her midback to buttocks. A stain on her back also was evident. Partial-thickness chemical burn was diagnosed. Review of the literature yielded 13 other cases of povidone-iodine-induced burn. This underrecognized adverse effect of povidone-iodine application typically occurs when the povidone-iodine has not been allowed to dry or has been trapped under the body of a patient in a pooled dependent position. The burn is usually seen immediately after the procedure or on the next day, and typically heals with minimum scarring within 3-4 weeks with conservative treatment. The commonly postulated mechanism is a chemical burn due to irritation coupled with maceration, friction, and pressure. Given the widespread use of povidone-iodine and the potential for development of infection after a burn, clinicians need to be aware of this possible povidone-iodine-associated adverse drug reaction, and of preventive measures.