2016/03/25 by Alexander Birbrair, Paul S. Frenette · 1 citation
Medicine · Immunology and Microbiology · #Hematopoietic Stem Cell Transplantation #T-cell and B-cell Immunology
paper · doi:10.1111/nyas.13016
openalex publication_date 2016/03/25 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
In adult mammals, hematopoietic stem cells (HSCs) are defined by their abilities to self-renew and to differentiate to form all blood cell lineages. These rare multipotent cells occupy specific locations in the bone marrow (BM) microenvironment. The specific microenvironment regulating HSCs, commonly referred to as the niche, comprises multiple cell types whose exact contributions are under active investigation. Understanding cellular cross talk involving HSCs in the BM microenvironment is of fundamental importance for harnessing therapies against benign and malignant blood diseases. In this review, we summarize and evaluate recent advances in our understanding of niche heterogeneity and its influence on HSC function.