2012/03/26 by Ryan M. O’Connell, Dinesh S. Rao, David Baltimore · 3 citations
Biochemistry, Genetics and Molecular Biology · #MicroRNA in disease regulation #Cancer-related molecular mechanisms research #Circular RNAs in diseases
paper · doi:10.1146/annurev-immunol-020711-075013
openalex publication_date 2012/03/26 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
The mammalian inflammatory response is a rapid and complex physiological reaction to noxious stimuli including microbial pathogens. Although inflammation plays a valuable role in combating infection, its dysregulation often occurs in people and can cause a variety of pathologies, ranging from chronic inflammation, to autoimmunity, to cancer. In recent years, our understanding of both the cellular and molecular networks that regulate inflammation has improved dramatically. Although much of the focus has been on the study of protein regulators of inflammation, recent evidence also points to a critical role for a specific class of noncoding RNAs, called microRNAs (miRNAs), in managing certain features of the inflammatory process. In this review, we discuss recent advances in our understanding of miRNAs and their connection to inflammatory responses. Additionally, we consider the link between perturbations in miRNA levels and the onset of human inflammatory diseases.