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High-resolution MRI: in vivo histology?

2005/11/28 by Holly Bridge, Stuart Clare · 1 citation
Neuroscience · Biochemistry, Genetics and Molecular Biology · #Neural dynamics and brain function #Cell Image Analysis Techniques #Functional Brain Connectivity Studies

paper · doi:10.1098/rstb.2005.1777

openalex publication_date 2005/11/28 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/15

Abstract

For centuries scientists have been fascinated with the question of how the brain works. Investigators have looked at both where different functions are localized and how the anatomical microstructure varies across the brain surface. Here we discuss how advances in magnetic resonance imaging (MRI) have allowed in vivo visualization of the fine structure of the brain that was previously only visible in post-mortem brains. We present data showing the correspondence between definitions of the primary visual cortex defined anatomically using very high-resolution MRI and functionally using functional MRI. We consider how this technology can be applied to allow the investigation of brains that differ from normal, and what this ever-evolving technology may be able to reveal about in vivo brain structure in the next few years.

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