Awakening guardian angels: drugging the p53 pathway

2009/11/23 by Christopher J. Brown, Sonia Lain, Sonia Laı́n +4 · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer-related Molecular Pathways #Protein Degradation and Inhibitors #Ubiquitin and proteasome pathways

paper · doi:10.1038/nrc2763

openalex publication_date 2009/11/23 · crossref created 2009/11/23 · crossref issued 2009/12/01 · crossref published 2009/12/01 · crossref published-print 2009/12/01 · crossref deposited 2023/05/19 · openalex created_date 2025/10/10 · crossref indexed 2026/07/21 · openalex updated_date 2026/07/31

Citations

• Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
• Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
• Structure-Based Design of Spiro-oxindoles as Potent, Specific Small-Molecule Inhibitors of the MDM2−p53 Interaction
• Restoration of p53 function leads to tumour regression in vivo

Cited by

• Drug discovery and mutant p53
• Experimental cancer treatment [wikipedia]