Modelling the burden caused by gene expression: an in silico investigation into the interactions between synthetic gene circuits and their chassis cell

2013/09/30 by Algar, Rhys, Ellis, Tom, Stan, Guy-Bart
#FOS: Biological sciences #Molecular Networks (q-bio.MN)

paper · doi:10.48550/arxiv.1309.7798

Abstract

In this paper we motivate and develop a model of gene expression for the purpose of studying the interaction between synthetic gene circuits and the chassis cell within which they are in- serted. This model focuses on the translational aspect of gene expression as this is where the literature suggests the crucial interaction between gene expression and shared resources lies.

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