2025/07/23 by Michael R. Harris, Ian A. Tonks · 1 voice
Chemistry · #Catalytic C–H Functionalization Methods #Catalytic Alkyne Reactions #Asymmetric Hydrogenation and Catalysis
paper · doi:10.1021/acscatal.5c03527
Strongly Lewis acidic titanium imido iodide complexes catalyze selective inter- and intramolecular carboamination of alkynes to give unsaturated imines. Computations and mechanistic experiments indicate that unsaturated imines are not necessarily the direct product of alkyne carboamination as previously reported but may also result from the ring-opening rearrangement of cyclopropylimines. Reactions of the cyclopropylimine products with titanium iodide complexes confirm the generation of acyclic imines can occur from an iminocyclopropane rearrangement.