Exosomes: Looking back three decades and into the future
2013/02/18 by Clifford V. Harding, John E. Heuser, Philip D. Stahl · 28 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Extracellular vesicles in disease #MicroRNA in disease regulation #Viral Infections and Vectors
paper · pdf · doi:10.1083/jcb.201212113
Abstract
Exosomes are extracellular membrane vesicles whose biogenesis by exocytosis of multivesicular endosomes was discovered in 1983. Since their discovery 30 years ago, it has become clear that exosomes contribute to many aspects of physiology and disease, including intercellular communication. We discuss the initial experiments that led to the discovery of exosomes and highlight some of the exciting current directions in the field.
Citations
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