2021/04/29 by Ghadi N. Alzhrani, Sarah T. Alanazi, Sumayyah Yasser Alsharif +6
Biochemistry, Genetics and Molecular Biology · #Extracellular vesicles in disease #MicroRNA in disease regulation #RNA Interference and Gene Delivery
paper · doi:10.1002/cbin.11620
openalex publication_date 2021/04/29 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
Exosomes are nano-sized bioactive vesicles of 30-150 nm in diameter. They are secreted by exocytosis of nearly all type of cells in to the extracellular fluid. Thereby, they can be found in many biological fluids. Exosomes regulate intracellular communication between cells via delivery of their cargo which include lipids, proteins, and nucleic acid. Many desirable features of exosomes made them promising candidates in several therapeutic applications. In this review, we discuss the use of exosomes as diagnostic tools and their possible biomedical applications. Additionally, current techniques used for isolation, purification, and characterization of exosomes from both biological fluids and in vitro cell cultures were discussed.