Estrogen Carcinogenesis in Breast Cancer

2006/01/18 by James D. Yager, Nancy E. Davidson · 11 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Estrogen and related hormone effects #Cancer Risks and Factors #Glutathione Transferases and Polymorphisms

paper · doi:10.1056/nejmra050776

openalex publication_date 2006/01/18 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Estrogen exposure is a major determinant of the risk of breast cancer. This article reviews how genotoxic, mutagenic metabolites of estrogen and stimulation of tissue growth by the hormone participate in the pathogenesis of breast cancer.

Citations

• Genotoxic metabolites of estradiol in breast: potential mechanism of estradiol induced carcinogenesis

Cited by

• Cytochrome P450 1B1–Mediated Estrogen Metabolism Results in Estrogen-Deoxyribonucleoside Adduct Formation
• Risk Factors of Breast Cancer
• Analysis of steroidal estrogen residues in food and environmental samples
• The use of high-dose estrogens for the treatment of breast cancer
• International Union of Basic and Clinical Pharmacology. XCVII. G Protein–Coupled Estrogen Receptor and Its Pharmacologic Modulators
• Pharmacology of Estrogens
• Steroid sulfatase: A pivotal player in estrogen synthesis and metabolism
• The selective estrogen receptor modulators in breast cancer prevention
• Estrogen Carcinogenesis in Breast Cancer
• Clinical Practice Guidelines for Multiple Endocrine Neoplasia Type 1 (MEN1)
• Carcinogen [wikipedia]