Lipoic acid metabolism and mitochondrial redox regulation

2017/11/30 by Ashley Solmonson, Ralph J. DeBerardinis · 33 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Biochemical Acid Research Studies #Coenzyme Q10 studies and effects #Alcoholism and Thiamine Deficiency

paper · pdf · doi:10.1074/jbc.tm117.000259

Abstract

-adenosylmethionine and iron-sulfur clusters. This cofactor is required for catalysis by multiple mitochondrial 2-ketoacid dehydrogenase complexes, including pyruvate dehydrogenase, α-ketoglutarate dehydrogenase, and branched-chain ketoacid dehydrogenase. Lipoic acid also plays a critical role in stabilizing and regulating these multienzyme complexes. Many of these dehydrogenases are regulated by reactive oxygen species, mediated through the disulfide bond of the prosthetic lipoyl moiety. Collectively, its functions explain why lipoic acid is required for cell growth, mitochondrial activity, and coordination of fuel metabolism.

Citations

• STUDIES ON A LIPOIC ACID-ACTIVATING SYSTEM
• A Trail of Research from Lipoic Acid to α-Keto Acid Dehydrogenase Complexes
• A New Metabolic Link
• Lipoic Acid Synthesis and Attachment in Yeast Mitochondria

Cited by

• Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells
• Copper induces cell death by targeting lipoylated TCA cycle proteins
• Copper homeostasis and cuproptosis in health and disease
• Small-molecule dissolution of stress granules by redox modulation benefits ALS models
• Ligand supplementation restores the cancer therapy efficacy of the antirheumatic drug auranofin from serum inactivation
• Boosting energy metabolism and biosynthesis in diverse organisms by a common bacterial salvage lipoylation protein
• Copper Metabolism and Cuproptosis: Molecular Mechanisms and Therapeutic Perspectives in Neurodegenerative Diseases
• Chemical priming of hypoxia responses via PLANT CYSTEINE OXIDASE inhibition improves flooding tolerance
• Frontline Science: Monocytes sequentially rewire metabolism and bioenergetics during an acute inflammatory response. [europepmc]
• The indispensable role of mammalian iron sulfur proteins in function and regulation of multiple diverse metabolic pathways. [europepmc]
• Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans. [europepmc]
• The role of lipid metabolism in aging, lifespan regulation, and age-related disease. [europepmc]
• CoA-dependent activation of mitochondrial acyl carrier protein links four neurodegenerative diseases. [europepmc]
• Exenatide induces frataxin expression and improves mitochondrial function in Friedreich ataxia. [europepmc]
• Nutritional and medical food therapies for diabetic retinopathy. [europepmc]
• Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria. [europepmc]
• Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis. [europepmc]
• CRISPR screens in physiologic medium reveal conditionally essential genes in human cells. [europepmc]
• ALDH1A3 Coordinates Metabolism With Gene Regulation in Pulmonary Arterial Hypertension. [europepmc]
• The effects of real and simulated microgravity on cellular mitochondrial function. [europepmc]
• Copper induces cell death by targeting lipoylated TCA cycle proteins. [europepmc]
• Compartmentalized metabolism supports midgestation mammalian development. [europepmc]
• A novel signature to guide osteosarcoma prognosis and immune microenvironment: Cuproptosis-related lncRNA. [europepmc]
• A practical guide for the analysis, standardization and interpretation of oxygen consumption measurements. [europepmc]
• Pan-cancer genetic analysis of cuproptosis and copper metabolism-related gene set. [europepmc]
• Functional spectrum and specificity of mitochondrial ferredoxins FDX1 and FDX2. [europepmc]
• Copper homeostasis and cuproptosis in health and disease. [europepmc]
• Molecular and Therapeutic Insights of Alpha-Lipoic Acid as a Potential Molecule for Disease Prevention. [europepmc]
• Cuproptosis: mechanisms and links with cancers. [europepmc]
• Mitochondrial fatty acid synthesis is an emergent central regulator of mammalian oxidative metabolism. [europepmc]
• Copper homeostasis and cuproptosis in atherosclerosis: metabolism, mechanisms and potential therapeutic strategies. [europepmc]
• Alpha-Lipoic Acid: Biological Mechanisms and Health Benefits. [europepmc]
• The molecular mechanism and therapeutic landscape of copper and cuproptosis in cancer. [europepmc]

Related

• Lipoic acid biosynthesis defects
• A New Metabolic Link
• Lipoic Acid Synthesis and Attachment in Yeast Mitochondria
• Differential diagnosis of lipoic acid synthesis defects
• Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells