2012/03/15 by Claire Martin, Gareth Matthews, Christopher Huang · 1 citation
Medicine · Biochemistry, Genetics and Molecular Biology · #Cardiac electrophysiology and arrhythmias #Ion channel regulation and function #Cardiac pacing and defibrillation studies
paper · pdf · doi:10.1136/heartjnl-2011-300953
openalex publication_date 2012/03/15 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22
Mutations involving cardiac ion channels result in abnormal action potential formation or propagation, leading to cardiac arrhythmias. Despite the large impact on society of sudden cardiac death resulting from such arrhythmias, understanding of the underlying cellular mechanism is poor and clinical risk stratification and treatment consequently limited. Basic research using molecular techniques, as well as animal models, has proved extremely useful in improving our knowledge of inherited arrhythmogenic syndromes. This offers the practitioner tools to accurately diagnose rare disorders and provides novel markers for risk assessment and a basis for new strategies of treatment.