Outside‐In Systems Pharmacology Combines Innovative Computational Methods With High‐Throughput Whole Vertebrate Studies

2018/04/25 by Pascal Schulthess, Rob C. van Wijk, Elke H. J. Krekels +3 · 1 citation
Biochemistry, Genetics and Molecular Biology · #Zebrafish Biomedical Research Applications #Receptor Mechanisms and Signaling #Gene Regulatory Network Analysis

paper · pdf · doi:10.1002/psp4.12297

openalex publication_date 2018/04/25 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

To advance the systems approach in pharmacology, experimental models and computational methods need to be integrated from early drug discovery onward. Here, we propose outside-in model development, a model identification technique to understand and predict the dynamics of a system without requiring prior biological and/or pharmacological knowledge. The advanced data required could be obtained by whole vertebrate, high-throughput, low-resource dose-exposure-effect experimentation with the zebrafish larva. Combinations of these innovative techniques could improve early drug discovery.

Citations

• Establishment and Optimization of a High Throughput Setup to Study <em>Staphylococcus epidermidis</em> and <em>Mycobacterium marinum</em> Infection as a Model for Drug Discovery
• Pharmacokinetic Modeling of Paracetamol Uptake and Clearance in Zebrafish Larvae: Expanding the Allometric Scale in Vertebrates with Five Orders of Magnitude
• Systems pharmacology of hepatic metabolism in zebrafish larvae

Cited by

• Zebrafish [wikipedia]