2016/01/01 by Rob C. van Wijk, Elke H. J. Krekels, Thomas Hankemeier +2 · 2 citations
Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Zebrafish Biomedical Research Applications #Receptor Mechanisms and Signaling #Pharmacogenetics and Drug Metabolism
paper · pdf · doi:10.1016/j.ddmod.2017.04.003
openalex publication_date 2016/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Interspecies translation of pharmacological processes needs to improve to reduce attrition in drug development. Systems pharmacology integrates systems biology and pharmacometrics to characterise and quantify system-specific behaviour upon exposure to drugs in different species. The zebrafish is a suitable vertebrate model organism for systems pharmacology, combining high-throughput potential with high genetic homology to higher vertebrates. Zebrafish larvae have been increasingly used for drug screens, but the influence of internal drug and metabolite exposure is hardly studied. Quantifying this internal exposure is essential for establishing both exposure-response and dose-exposure relationships, needed for translation. The zebrafish may also serve as a suitable model species for translational studies on the occurrence of hepatotoxicity and the influence of hepatic dysfunction on drug metabolism.