The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity

2010/11/13 by Gregory M. Miller · 3 citations
Neuroscience · Biochemistry, Genetics and Molecular Biology · #Neurotransmitter Receptor Influence on Behavior #Receptor Mechanisms and Signaling #Neuroscience and Neuropharmacology Research

paper · doi:10.1111/j.1471-4159.2010.07109.x

openalex publication_date 2010/11/13 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

It is now recognized that trace amine associated-receptor 1 (TAAR1) plays a functional role in the regulation of brain monoamines and the mediation of action of amphetamine-like psychostimulants. Accordingly, research on TAAR1 opens the door to a new avenue of approach for medications development to treat drug addiction as well as the spectrum of neuropsychiatric disorders hallmarked by aberrant regulation of brain monoamines. This overview focuses on recent studies which reveal a role for TAAR1 in the functional regulation of monoamine transporters and the neuronal regulatory mechanisms that modulate dopaminergic activity.

Citations

• Trace amine-associated receptor 1 as a monoaminergic modulator in brain
• A renaissance in trace amines inspired by a novel GPCR family
• Amphetamine, 3,4-Methylenedioxymethamphetamine, Lysergic Acid Diethylamide, and Metabolites of the Catecholamine Neurotransmitters Are Agonists of a Rat Trace Amine Receptor

Cited by

• Amphetamine [wikipedia]
• Libido [wikipedia]
• Neurotransmitter [wikipedia]