Trace amine-associated receptor 1 as a monoaminergic modulator in brain

2009/05/30 by Zhihua Xie, Gregory M. Miller · 27 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Receptor Mechanisms and Signaling #Neurotransmitter Receptor Influence on Behavior #Neuroscience and Neuropharmacology Research

paper · doi:10.1016/j.bcp.2009.05.031

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• The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity
• Trace amine-associated receptor 1 is a stereoselective binding site for compounds in the amphetamine class
• Behavioral disinhibition and reduced anxiety-like behaviors in monoamine oxidase B-deficient mice. [europepmc]
• Normal thermoregulatory responses to 3-iodothyronamine, trace amines and amphetamine-like psychostimulants in trace amine associated receptor 1 knockout mice. [europepmc]
• Functional evolution of the trace amine associated receptors in mammals and the loss of TAAR1 in dogs. [europepmc]
• The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity. [europepmc]
• Electrophysiological effects of trace amines on mesencephalic dopaminergic neurons. [europepmc]
• Large candidate gene association study reveals genetic risk factors and therapeutic targets for fibromyalgia. [europepmc]
• Trace amine-associated receptor 1 is a stereoselective binding site for compounds in the amphetamine class. [europepmc]
• Augmentation of methamphetamine-induced behaviors in transgenic mice lacking the trace amine-associated receptor 1. [europepmc]
• Avenues for the development of therapeutics that target trace amine associated receptor 1 (TAAR1). [europepmc]
• The trace amine associated receptor 1 agonist RO5263397 attenuates the induction of cocaine behavioral sensitization in rats. [europepmc]
• Trace Amines and the Trace Amine-Associated Receptor 1: Pharmacology, Neurochemistry, and Clinical Implications. [europepmc]
• Role of TAAR1 within the Subregions of the Mesocorticolimbic Dopaminergic System in Cocaine-Seeking Behavior. [europepmc]
• Possible role of rare variants in Trace amine associated receptor 1 in schizophrenia. [europepmc]
• Hypothesizing that, A Pro-Dopamine Regulator (KB220Z) Should Optimize, but Not Hyper-Activate the Activity of Trace Amine-Associated Receptor 1 (TAAR-1) and Induce Anti-Craving of Psychostimulants in the Long-Term. [europepmc]
• TAAR1 in Addiction: Looking Beyond the Tip of the Iceberg. [europepmc]
• Differential genetic risk for methamphetamine intake confers differential sensitivity to the temperature-altering effects of other addictive drugs. [europepmc]
• Reproducing the dopamine pathophysiology of schizophrenia and approaches to ameliorate it: a translational imaging study with ketamine. [europepmc]
• Olfactory expression of trace amine-associated receptors requires cooperative cis-acting enhancers. [europepmc]
• Trace Amine-Associated Receptor 1 Trafficking to Cilia of Thyroid Epithelial Cells. [europepmc]
• Enhancer Regulation of Dopaminergic Neurochemical Transmission in the Striatum. [europepmc]
• Selective TAAR1 agonists induce conditioned taste aversion. [europepmc]
• G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders. [europepmc]
• T1AM/TAAR1 System Reduces Inflammatory Response and β-Amyloid Toxicity in Human Microglial HMC3 Cell Line. [europepmc]
• Molecular basis of human trace amine-associated receptor 1 activation. [europepmc]
• Illicit Drugs in Surface Waters: How to Get Fish off the Addictive Hook. [europepmc]