2017/01/20 by Friedrich Frischknecht, Kai Matuschewski · 1 citation
Medicine · Immunology and Microbiology · #Malaria Research and Control #Mosquito-borne diseases and control #Invertebrate Immune Response Mechanisms
paper · pdf · doi:10.1101/cshperspect.a025478
openalex publication_date 2017/01/20 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04
sporozoite transmission is a critical population bottleneck in parasite life-cycle progression and, hence, a target for prophylactic drugs and vaccines. The recent progress of a candidate antisporozoite subunit vaccine formulation to licensure highlights the importance of sporozoite transmission intervention in the malaria control portfolio. Sporozoites colonize mosquito salivary glands, migrate through the skin, penetrate blood vessels, breach the liver sinusoid, and invade hepatocytes. Understanding the molecular and cellular mechanisms that mediate the remarkable sporozoite journey in the invertebrate vector and the vertebrate host can inform evidence-based next-generation drug development programs and immune intervention strategies.