Intravital microscopy demonstrating antibody-mediated immobilisation of Plasmodium berghei sporozoites injected into skin by mosquitoes

2004/07/02 by Jerome P. Vanderberg, Ute Frevert · 28 citations
Medicine · #Mosquito-borne diseases and control #Malaria Research and Control #Research on Leishmaniasis Studies

paper · doi:10.1016/j.ijpara.2004.05.005

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• Protective antibodies target cryptic epitope unmasked by cleavage of malaria sporozoite protein
• Intravital observation of Plasmodium berghei sporozoite infection of the liver. [europepmc]
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• Acquired immunity to malaria. [europepmc]
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• Plasmodium sporozoite-host interactions from the dermis to the hepatocyte. [europepmc]
• Genetically engineered, attenuated whole-cell vaccine approaches for malaria. [europepmc]
• Immunological mechanisms underlying protection mediated by RTS,S: a review of the available data. [europepmc]
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• The skin: where malaria infection and the host immune response begin. [europepmc]
• Pre-erythrocytic malaria vaccines: identifying the targets. [europepmc]
• Role of host cell traversal by the malaria sporozoite during liver infection. [europepmc]
• Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection. [europepmc]
• Model for in vivo assessment of humoral protection against malaria sporozoite challenge by passive transfer of monoclonal antibodies and immune serum. [europepmc]
• Malaria immunity in man and mosquito: insights into unsolved mysteries of a deadly infectious disease. [europepmc]
• Sporozoite immunization of human volunteers under chemoprophylaxis induces functional antibodies against pre-erythrocytic stages of Plasmodium falciparum. [europepmc]
• Direct venous inoculation of Plasmodium falciparum sporozoites for controlled human malaria infection: a dose-finding trial in two centres. [europepmc]
• Longitudinal analysis of Plasmodium sporozoite motility in the dermis reveals component of blood vessel recognition. [europepmc]
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• Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children. [europepmc]
• Antibody-Mediated Protection against Plasmodium Sporozoites Begins at the Dermal Inoculation Site. [europepmc]
• A Potent Anti-Malarial Human Monoclonal Antibody Targets Circumsporozoite Protein Minor Repeats and Neutralizes Sporozoites in the Liver. [europepmc]
• A Monoclonal Antibody for Malaria Prevention. [europepmc]