2011/11/01 by Jose M. G. Vilar, José M. G. Vilar, Leonor Saiz · 1 citation
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Physics and Astronomy · #Biological system #Biology #Cell Adhesion Molecules Research #Cell biology #Chemistry #Computer science #Extracellular #Gene Regulatory Network Analysis #Intracellular #Intracellular transport #Protein Kinase Regulation and GTPase Signaling #Signal transduction #physics.bio-ph #q-bio.MN #q-bio.SC
paper · pdf · doi:10.1016/j.bpj.2011.09.035
published as Biophys. J. 101, 2315-2323 (2011) · 17 pages, 5 figures
openalex publication_date 2011/11/01 · arxiv created 2011/11/17 · arxiv updated 2011/11/18 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05
Many cellular networks rely on the regulated transport of their components to transduce extracellular information into precise intracellular signals. The dynamics of these networks is typically described in terms of compartmentalized chemical reactions. There are many important situations, however, in which the properties of the compartments change continuously in a way that cannot naturally be described by chemical reactions. Here, we develop an approach based on transport along a trafficking coordinate to precisely describe these processes and we apply it explicitly to the TGF-β signal transduction network, which plays a fundamental role in many diseases and cellular processes. The results of this newly introduced approach accurately capture for the first time the distinct TGF-β signaling dynamics of cells with and without cancerous backgrounds and provide an avenue to predict the effects of chemical perturbations in a way that closely recapitulates the observed cellular behavior.