Membrane Trafficking of G Protein–Coupled Receptors

2004/01/27 by Christopher M. Tan, Ashley E. Brady, Hilary Highfield Nickols +2 · 1 citation
Biochemistry, Genetics and Molecular Biology · Neuroscience · Medicine · #Receptor Mechanisms and Signaling #Neuropeptides and Animal Physiology #Diabetes Treatment and Management

paper · doi:10.1146/annurev.pharmtox.44.101802.121558

openalex publication_date 2004/01/27 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/15

Abstract

G protein-coupled receptors (GPCRs) modulate diverse physiological and behavioral signaling pathways by virtue of changes in receptor activation and inactivation states. Functional changes in receptor properties include dynamic interactions with regulatory molecules and trafficking to various cellular compartments at various stages of the life cycle of a GPCR. This review focuses on trafficking of GPCRs to the cell surface, stabilization there, and agonist-regulated turnover. GPCR interactions with a variety of newly revealed partners also are reviewed with the intention of provoking further analysis of the relevance of these interactions in GPCR trafficking, signaling, or both. The disease consequences of mislocalization of GPCRs also are described.

Citations

• The Interaction of β-Arrestin with the AP-2 Adaptor Is Required for the Clustering of β2-Adrenergic Receptor into Clathrin-coated Pits
• Heterodimerization is required for the formation of a functional GABAB receptor
• The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals
• A Trafficking Checkpoint Controls GABAB Receptor Heterodimerization
• An amino-acid taste receptor
• 14-3-3 Proteins: Structure, Function, and Regulation
• THE ROLE OF RECEPTOR KINASES AND ARRESTINS IN G PROTEIN–COUPLED RECEPTOR REGULATION
• Signals for Sorting of Transmembrane Proteins to Endosomes and Lysosomes
• Evolving Concepts in G Protein-Coupled Receptor Endocytosis: The Role in Receptor Desensitization and Signaling

Cited by

• G protein-coupled receptor [wikipedia]