2004/03/19 by Maria Barbi, M. Barbi, C. Place +5 · 33 citations
Biochemistry, Genetics and Molecular Biology · Mathematics · Physics and Astronomy · #Artificial intelligence #Base (topology) #Base pair #Biology #Biophysics #Computational biology #Computer science #DNA #DNA and Nucleic Acid Chemistry #Diffusion and Search Dynamics #Genetics #Mathematics #Motion (physics) #Noise (video) #Polymerase #RNA and protein synthesis mechanisms #Random walk #Sequence (biology) #Statistics #cond-mat.soft #physics.bio-ph #q-bio.BM
paper · pdf · doi:10.1103/physreve.70.041901
published in Physical Review E 70(4), 041901 (American Physical Society) · 12 pages, 3 figures
arxiv created 2004/03/19 · openalex publication_date 2004/10/06 · arxiv updated 2011/07/13 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
The possibility that the sliding motion of proteins on DNA is influenced by the base sequence through a base pair reading interaction, is considered. Referring to the case of the T7 RNA-polymerase, we show that the protein should follow a noise-influenced sequence-dependent motion which deviate from the standard random walk usually assumed. The general validity and the implications of the results are discussed.