Singing Mice, Songbirds, and More: Models for FOXP2 Function and Dysfunction in Human Speech and Language

2006/10/11 by Stephanie A. White, Simon E. Fisher, Daniel H. Geschwind +2 · 3 citations
Biochemistry, Genetics and Molecular Biology · Psychology · Social Sciences · #Animal Vocal Communication and Behavior #Language Development and Disorders #Child Development and Digital Technology

paper · pdf · doi:10.1523/jneurosci.3379-06.2006

openalex publication_date 2006/10/11 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

In 2001, a point mutation in the forkhead box P2 (FOXP2) coding sequence was identified as the basis of an inherited speech and language disorder suffered by members of the family known as "KE." This mini-symposium review focuses on recent findings and research-in-progress, primarily from five laboratories. Each aims at capitalizing on the FOXP2 discovery to build a neurobiological bridge between molecule and phenotype. Below, we describe genetic through behavioral techniques used currently to investigate FoxP2 in birds, rodents, and humans for discovery of the neural bases of vocal learning and language.

Citations

• The Faculty of Language: What Is It, Who Has It, and How Did It Evolve?

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• Birdsong Learning and Culture: Analogies with Human Spoken Language
• Developmental verbal dyspraxia [wikipedia]