Why in vivo models of disease remain indispensable
2026/04/01 by Debora Bogani, Kirsty Hooper, Owen Sansom · 4 voices
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Veterinary · #Animal model #Animal testing and alternatives #Complex disease #Computational model #Disease #Immunotoxicology and immune responses #Model validation #Zebrafish Biomedical Research Applications
paper · doi:10.1242/dmm.052997
openalex publication_date 2026/04/01 · openalex created_date 2026/05/06 · openalex updated_date 2026/07/31
Abstract
Summary: The call to arms for alternatives to model organisms of disease will fail without ongoing integration with – and validation against – complex animal models and support from the animal modelling community.
Discussions
- Interesting! doi.org/10.1242/dmm.... "Debates about animal research & alternatives are often framed as a contest between old and new approaches. This framing is both misleading and counterproductive. [bsky, 20 points, 0 comments]
- Excited to see this new #OpenAccess perspective on the future of preclinical research published in #DMM. How animal models, #organoids, #AI and other methodologies can improve translation and #biomedi [bsky, 11 points, 0 comments]
- With new regulations taking effect, the question of which models best capture human disease is becoming increasingly urgent. In our April Editorial, we discuss why in vivo disease models remain essent [bsky, 2 points, 0 comments]
- Bogani et al say: "In this integrated future, animal models are not an obstacle to progress..." doi.org/10.1242/dmm.... Reviewers that favor them can be, though! We agree that journals must play a [bsky, 0 points, 1 comments]
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