Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation

2016/06/13 by Pu-Hyeon Cha, Yong‐Hee Cho, Yong-Hee Cho +20 · 4 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer-related Molecular Pathways #Cancer-related gene regulation #Wnt/β-catenin signaling in development and cancer

paper · doi:10.1038/nchembio.2103

crossref issued 2016/06/13 · crossref published 2016/06/13 · crossref published-online 2016/06/13 · openalex publication_date 2016/06/13 · crossref created 2016/06/13 · crossref published-print 2016/08/01 · crossref deposited 2023/05/18 · openalex created_date 2025/10/10 · crossref indexed 2026/04/09 · openalex updated_date 2026/07/23

Citations

• Cancer Statistics, 2009
• Ras Stabilization Through Aberrant Activation of Wnt/β-Catenin Signaling Promotes Intestinal Tumorigenesis

Cited by

• β‐Catenin‐RAS interaction serves as a molecular switch for RAS degradation via GSK3β
• WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation
• Targeting the β-catenin signaling for cancer therapy
• Kang-Yell Choi [wikipedia]