2008/06/30 by H. Grzeschik, R. J. Harris, Rosemary J. Harris +2 · 21 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Mathematics · Physics and Astronomy · #Chemistry #Classical mechanics #Condensed matter physics #Current (fluid) #Intracellular #Intracellular transport #Lattice (music) #Materials science #Mathematics #Molecular motor #Nanotechnology #Physics #Protein filament #Random walk #Statistical physics #Statistics #Stochastic processes and statistical mechanics #Theoretical and Computational Physics #Thermodynamics #cond-mat.stat-mech #q-bio.SC #stochastic dynamics and bifurcation
paper · pdf · doi:10.1103/physreve.81.031929
published in Physical Review E 81(3), 031929 (American Physical Society) · 15 pages, 13 figures; revised version (to appear in Phys. Rev. E)
arxiv created 2010/02/19 · openalex publication_date 2010/03/31 · arxiv updated 2010/04/27 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05
Motivated by experimental results on the interplay between molecular motors and tau proteins, we extend lattice-based models of intracellular transport to include a second species of particle which locally influences the motor-filament attachment rate. We consider various exactly solvable limits of a stochastic multiparticle model before focusing on the low-motor-density regime. Here, an approximate treatment based on the random-walk behavior of single motors gives good quantitative agreement with simulation results for the tau dependence of the motor current. Finally, we discuss the possible physiological implications of our results.