Camps Reaction and Related Cyclizations

2020/11/01 by Alexander S. Fisyuk, A. S. Kostyuchenko, Д. С. Гончаров · 1 citation
Chemistry · #Chemical synthesis and alkaloids #Synthesis and Reactivity of Heterocycles #Asymmetric Synthesis and Catalysis

paper · doi:10.1134/s1070428020110019

openalex publication_date 2020/11/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30

Abstract

The review presents analysis of the literature on the intramolecular cyclization of N-(2-acylaryl)amides, known as the Camps reaction, as well as close analogs of these compounds, N-(3-oxoalkenyl)- and N-(3-oxoalkyl)amides, which contain an amide and a carbonyl groups and react by the aldol–crotonic type. The potential, limitations, and regularities of these reactions leading to quinoline-2(1H)-ones, quinoline-4(1H)-ones, pyridin-2-ones, pyridin-4-ones, as well as their hydrogenated derivatives are highlighted.

Citations

• Sequential Cu-Catalyzed Amidation-Base-Mediated Camps Cyclization: A Two-Step Synthesis of 2-Aryl-4-quinolones from o-Halophenones

Cited by

• Camps quinoline synthesis [wikipedia]

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