2003/06/24 by Ralf Metzler, Joseph Klafter · 117 citations
Biochemistry, Genetics and Molecular Biology · Engineering · Physics and Astronomy · #Biomolecule #Brownian dynamics #Brownian motion #Chromosomal translocation #DNA and Nucleic Acid Chemistry #Dynamics (music) #Lipid Membrane Structure and Behavior #Markov chain #Markov process #Molecular dynamics #Molecule #Nanopore and Nanochannel Transport Studies #cond-mat.stat-mech #q-bio
paper · pdf · doi:10.1016/s0006-3495(03)74699-2
published in Biophysical Journal 85(4), 2776-2779 (Elsevier BV) · 5 pages, 2 figures, RevTeX4, submitted to Biophys. J
arxiv created 2003/06/24 · openalex publication_date 2003/10/01 · arxiv updated 2009/11/30 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/05
Recent single molecule experiments probing the passage process of a short single-stranded DNA (ssDNA) through a membrane channel (translocation) allow to measure the passage time distribution. Building on a recent modelling approach (D. K. Lubensky and D. R. Nelson, Biophys. J. 77, 1824 (1999)), which has been demonstrated to be valid for chains of up to ≃ 300 nucleotides and therefore well applies to the system we have in mind, we discuss the consequences if the associated dynamics is not of Markov origin, but if strong memory effects prevail during the translocation. Motivation is drawn from recent results indicating that the distribution of translocation times is broader than predicted by simple Markovian models based on Brownian motion.