Staphylococcus aureus Fibronectin Binding Protein A Mediates Biofilm Development and Infection

2020/02/11 by Casey M. Gries, Trevor Biddle, Jeffrey L. Bose +3 · 26 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Immunology and Microbiology · #Bacterial biofilms and quorum sensing #Antimicrobial Resistance in Staphylococcus #Antimicrobial Peptides and Activities

paper · doi:10.1128/iai.00859-19

Abstract

Implanted medical device-associated infections pose significant health risks, as they are often the result of bacterial biofilm formation. Staphylococcus aureus is a leading cause of biofilm-associated infections which persist due to mechanisms of device surface adhesion, biofilm accumulation, and reprogramming of host innate immune responses. We found that the S. aureus fibronectin binding protein A (FnBPA) is required for normal biofilm development in mammalian serum and that the SaeRS two-component system is required for functional FnBPA activity in serum.

Citations

• Periprosthetic Joint Infection: The Incidence, Timing, and Predisposing Factors

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