2014/01/01 by Fábio Renato Pereira, Mário F. C. Santos, David E. Williams +4 · 1 citation
Biochemistry, Genetics and Molecular Biology · Chemistry · Environmental Science · #Marine Sponges and Natural Products #Marine Toxins and Detection Methods #Synthetic Organic Chemistry Methods
paper · doi:10.5935/0103-5053.20140037
openalex publication_date 2014/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/27
In the present investigation, two specimens of the nudipleuran mollusc Pleurobranchus areolatus have shown to accumulate oxidized rodriguesin A derivatives. Rodriguesic acid presents a carboxylic acid replacing the terminal methyl group of the alkyl chain of rodriguesin A. A hydroxamate group was also present on the diketopiperazine moiety of a rodriguesic acid derivative. The structures of both rodriguesic acid and of rodriguesic acid hydroxamate have been established by analysis of spectroscopic data, including their absolute configuration. Two methyl esters of the rodriguesic acids have been isolated as major compounds, but were considered to be isolation artifacts.