2008/05/21 by Celso A. Câmara, Celso A. Camara, Tânia Maria Sarmento Silva +8
Environmental Science · Immunology and Microbiology · Medicine · #Papaya Research and Applications #Parasite Biology and Host Interactions #Parasites and Host Interactions
paper · pdf · doi:10.1590/s0001-37652008000200011
openalex publication_date 2008/05/21 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
The toxic profile of lawsone (2-hydroxy-[1,4]naphthoquinone) and a series of [1,4]naphthoquinone derivatives was evaluated against the brine shrimp Artemia salina and against the mollusk Biomphalaria glabrata, the main transmitting vector of schistosomiasis in Brazil. Of the seventeen compounds tested nine fell below the threshold of 100 microg/mL set for potential molluscicidal activity by the World Health Organization. As a general rule derivatives with non-polar substituents presented the highest molluscicidal activities. These substances showed significant toxicity in A. salina lethality bioassay.