A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain

2010/05/01 by Christopher J. Bohlen, Avi Priel, Sharleen Zhou +4 · 4 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Neuroscience · #Ion Channels and Receptors #Ion channel regulation and function #Toxin Mechanisms and Immunotoxins

paper · pdf · doi:10.1016/j.cell.2010.03.052

crossref issued 2010/05/01 · crossref published 2010/05/01 · crossref published-print 2010/05/01 · openalex publication_date 2010/05/01 · crossref created 2010/05/28 · crossref deposited 2025/09/25 · openalex created_date 2025/10/10 · crossref indexed 2026/05/18 · openalex updated_date 2026/07/28

Citations

• Spider toxins activate the capsaicin receptor to produce inflammatory pain
• AN INTRODUCTION TO TRP CHANNELS
• The Structure of the Potassium Channel: Molecular Basis of K + Conduction and Selectivity

Cited by

• A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1
• Spider Envenomation in Australia
• TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
• RhTx [wikipedia]