2013/10/10 by Klaus Speck, Thomas Magauer · 1 citation
Chemistry · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Advanced Synthetic Organic Chemistry #Alkaloids: synthesis and pharmacology #Microbial Natural Products and Biosynthesis
paper · pdf · doi:10.3762/bjoc.9.243
openalex publication_date 2013/10/10 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
This review highlights the chemical and biological aspects of natural products containing an oxidized or reduced isoindole skeleton. This motif is found in its intact or modified form in indolocarbazoles, macrocyclic polyketides (cytochalasan alkaloids), the aporhoeadane alkaloids, meroterpenoids from Stachybotrys species and anthraquinone-type alkaloids. Concerning their biological activity, molecular structure and synthesis, we have limited this review to the most inspiring examples. Within different congeners, we have selected a few members and discussed the synthetic routes in more detail. The putative biosynthetic pathways of the presented isoindole alkaloids are described as well.