1994/03/31 by Norihiko Tánimoto, Samuel W. Gerritz, Akiyoshi Sawabe +3 · 1 citation
Chemistry · Engineering · #Aldol reaction #Asymmetric Synthesis and Catalysis #Axial and Atropisomeric Chirality Synthesis #Catalysis #Chemistry #Computer science #Coupling (piping) #Enantioselective synthesis #Engineering #Fragment (logic) #Organic chemistry #Programming language #Stereochemistry #Stereoselectivity #Synthetic Organic Chemistry Methods #Total synthesis
paper · doi:10.1002/anie.199406731
openalex publication_date 1994/03/31 · openalex created_date 2025/10/10 · openalex updated_date 2025/11/06
Several intriguing transformations culminated in the first total synthesis of the title compound 1—the nonnatural ent-1 had been published previously—on coupling the fragments A, A′, B, and C. Crucial steps of the synthesis are the aldol reactions in the construction of fragment B, which solved the tricky problem of the stereoselective coupling of chiral fragments.