BODIPY phototether enables oligonucleotide cyclization and subsequent deprotection by tissue-transparent red light

2024/01/01 by Lucie Wohlrábová, Marlen Sahlbach, Alexander Heckel +1 · 1 voice
Biochemistry, Genetics and Molecular Biology · Materials Science · #Luminescence and Fluorescent Materials #Photochromic and Fluorescence Chemistry #RNA Interference and Gene Delivery

paper · pdf · doi:10.1039/d4cc00272e

openalex publication_date 2024/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/11

Abstract

-methyl-BODIPY photocages release a leaving group upon visible light irradiation but often lack thermal stability. In turn, our thermally-stable, red-shifted BODIPY phototether allows oligonucleotide cyclization, preventing complementary strand hybridization. Hybridization resumes upon red-NIR irradiation, disconnecting the phototether by oxidative cleavage, which is easily monitored by a blue shift in fluorescence.

Citations

• Therapeutic Antisense Oligonucleotides Are Coming of Age

Discussions

• #research BODIPY phototether enables oligonucleotide cyclization and subsequent deprotection by tissue-transparent red light (Slanina) - ChemCommun: doi.org/10.1039/D4CC... [bsky, 0 points, 0 comments]

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