Phototoxicity of hydroxymethyl-BODIPYs: are photocages that innocent?

2025/01/01 by Kirill M. Kuznetsov, Pierre Mesdom, Kallol Purkait +4 · 1 voice · 1 citation
Materials Science · Engineering · #Luminescence and Fluorescent Materials #Nanoplatforms for cancer theranostics #Photochromic and Fluorescence Chemistry

paper · pdf · doi:10.1039/d5sc04032a

Abstract

a type I photodynamic therapy (PDT) mechanism. These findings highlight the need for greater scrutiny of photocages themselves in biological studies. Far from being inert carriers, they may exert substantial biological effects, and in some cases, their activity could even surpass that of the released therapeutic agent.

Cited by

• Optimized Xanthenium Photocages with Fused Ring Systems for Photoactivated Chemotherapy and G Protein-Coupled Receptor Photopharmacology. [europepmc]

Discussions

• Congrats to @kirillkuznetsov.bsky.social for his article just accepted in @chemicalscience.rsc.org on the (photo-)toxicity of some photocages, which were found to be far from being inert carriers. Won [bsky, 33 points, 1 comments]

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