2021/01/01 by Xincai Zhao, Rong Xu, Yonggang Wang +5
Medicine · Pharmacology, Toxicology and Pharmaceutics · #Medication Adherence and Compliance #Pharmaceutical Practices and Patient Outcomes #Pharmacovigilance and Adverse Drug Reactions
paper · pdf · doi:10.1177/00469580211009662
crossref issued 2021/01/01 · crossref published 2021/01/01 · crossref published-print 2021/01/01 · openalex publication_date 2021/01/01 · crossref published-online 2021/04/13 · crossref created 2021/04/13 · openalex created_date 2025/10/10 · crossref deposited 2026/04/29 · crossref indexed 2026/07/29 · openalex updated_date 2026/07/30
Pharmacists are health care professionals who are actively involved in identifying and solving drug-related problems (DRPs) in neoplasm patients. However, the effectiveness of pharmaceutical services at outpatient clinic for neoplasm patients have not been reported in China. This study aims to describe and investigate the impacts of pharmacists-managed oncology outpatient clinic on ambulatory neoplasm patients. We performed a descriptive, prospective study from June 6, 2018 to June 6, 2020. Firstly, we established a pharmacists-managed oncology outpatient clinic and a Pharmacists Work System of Medication Therapy Management (MTM) software with the cooperation of oncologists, pharmacists and software engineers in 2018. Subjects were neoplasm patients who visited the pharmacists-managed outpatient clinic. The pharmacists performed a comprehensive assessment of the patient's medication and made planned interventions based on the DRPs identified. A total of 215 eligible patients with 707 visits were enrolled and recorded in the MTM software. A total of 316 DRPs (1.47 per patient) were identified. Adverse reactions, non-adherence, untreated indication, and drug interactions were the leading DRPs. 261 (82.6%) of the identified DRPs had been confirmed as resolved and 104 (78.2%) of adverse reactions were improved following pharmacist interventions and 2 to 3 course follow-up. Of the 382 planned interventions, 345 (90.3%) were accepted by patients or physicians. This is the first pharmacists-managed oncology outpatient clinic to describe the type of DRPs in neoplasm patients and evaluate the effectiveness of pharmacist interventions in China. Pharmacist interventions were efficacious in resolving DRPs and improving adverse reactions. We confirmed that pharmacists have an important role in ambulatory neoplasm patients care.