Kaempferol targets Src to exert its chemopreventive effects on mammary tumorigenesis via regulation of the PI3K/AKT pathway

2025/03/29 by Pinghan Wang, Yu Ma, Xiaohui Rao +4 · 1 voice
Biochemistry, Genetics and Molecular Biology · Medicine · #Ferroptosis and cancer prognosis #PI3K/AKT/mTOR signaling in cancer #Pharmacological Effects of Medicinal Plants

paper · doi:10.1016/j.phymed.2025.156701

openalex publication_date 2025/03/29 · crossref created 2025/03/29 · crossref issued 2025/06/01 · crossref published 2025/06/01 · crossref published-print 2025/06/01 · openalex created_date 2025/10/10 · crossref deposited 2025/11/05 · crossref indexed 2026/05/06 · openalex updated_date 2026/08/02

Citations

• Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
• PLIP 2021: expanding the scope of the protein–ligand interaction profiler to DNA and RNA
• Hallmarks of Cancer: New Dimensions
• Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Discussions

• Hmm, if Src/Pi3k/Akt signaling is also active in LongCovid MECFS, could kaempferol be effective? 🤔 fyi doi.org/10.1016/j.ph... In addition, NMN, NAC, and lithium also act on this pathway—all substan [bsky, 0 points, 1 comments]