8,14- seco-ent -Kaurane diterpenoids from Isodon glutinosus : enol–enol tautomerism and antitumor activity

2025/01/01 by Yang-Yang Fu, Kun Hu, Song-Yu Hou +5 · 1 voice
Biochemistry, Genetics and Molecular Biology · #Bioactive Natural Diterpenoids Research

paper · doi:10.1039/d5qo00356c

openalex publication_date 2025/01/01 · openalex created_date 2025/03/27 · openalex updated_date 2026/07/10

Abstract

Structures and enol–enol tautomerism of glutinosasins A–D, four novel 8,14- seco-ent -kaurane diterpenoids from Isodon glutinosus , were elucidated via quantum chemical calculations. Notably, glutinosasin D selectively inhibited SW480 tumor cells.

Citations

• CREST—A program for the exploration of low-energy molecular chemical space
• A comprehensive electron wavefunction analysis toolbox for chemists, Multiwfn

Discussions

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