2018/12/09 by Kai‐Long Ji, Kai-Long Ji, Yao‐Yue Fan +12 · 2 citations
Biochemistry, Genetics and Molecular Biology · #Plant biochemistry and biosynthesis #Bioactive Natural Diterpenoids Research #Natural product bioactivities and synthesis
paper · doi:10.1021/acs.joc.8b02665
Four highly rearranged labdane-type diterpenoids, maximumins A-D (1-4) possessing different new carbon skeletons, together with a biosynthetically related known analog 5 were isolated from Amomum maximum. The structures of new compounds with absolute configurations were characterized by spectroscopic and computational approaches. The plausible biogenetic pathways for 1-4 were proposed. These compounds showed moderate to weak activities against nuclear factor kappa B (NF-κB).