2025/03/27 by Stephen Gibbons, Borislava Jassim, Clare Spencer +3 · 1 voice
Medicine · Psychology · #Sexual function and dysfunction studies #Sexuality, Behavior, and Technology #Hormonal and reproductive studies
paper · pdf · doi:10.3399/bjgp25x741321
openalex publication_date 2025/03/27 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/11
What is hypoactive sexual desire disorder?Hypoactive sexual desire disorder (HSDD) presents a persistent absence or deficiency of sexual fantasies and desire, in some individuals leading to significant distress or interpersonal difficulty. 1 While its aetiology encompasses various biological, psychological, and social factors, testosterone deficiency is recognised as a potential contributor.Testosterone replacement therapy (TRT) has been explored as a treatment option for individuals with HSDD during the menopause, particularly those with low testosterone levels.However, its efficacy remains debatable, with inconsistent results observed across studies. 2 Additionally, testosterone supplementation carries potential risks of adverse effects including acne, increased body hair at site of application, generalised hirsutism, alopecia, mood changes, deepening of the voice, and enlarged clitoris, some of which may be irreversible. 3Therefore, the use of testosterone in treating HSDD necessitates careful consideration, individualised approaches, and close monitoring by healthcare professionals.