2025/05/10 by Sarah E. Polk, Fredrik Öhman, Jason Hassenstab +4 · 1 voice · 2 citations
Medicine · Neuroscience · Psychology · #Cognitive Functions and Memory #Dementia and Cognitive Impairment Research #Functional Brain Connectivity Studies
paper · pdf · doi:10.1038/s41746-025-01583-5
openalex publication_date 2025/05/10 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/23
Characterizing subtle cognitive changes in preclinical Alzheimer's disease (AD) is difficult using traditional neuropsychological assessments. Remote and unsupervised digital assessments can improve scalability, measurement reliability, and ecological validity, enabling the capture of subtle changes. We evaluate such tools for use in preclinical AD, or cognitively unimpaired individuals with abnormal levels of AD pathology. We screened 1904 reports for studies remotely assessing cognition in preclinical AD samples. Twenty-three tools were identified, and their usability, reliability, and validity, including construct and criterion validity based on in-person neuropsychological and Aβ/tau measures, was reported. We present a necessary update to a rapidly evolving field, following our previous review (Öhman et al., 2021) and address open questions of feasibility and reliability of remote testing in older adults. Future applications of such tools are discussed, including longitudinal monitoring of cognition, scalable case finding, and individualized prognostics in both clinical trials and healthcare contexts.