Rational design of polymer-based mRNA delivery systems for cancer treatment

2024/01/01 by Qianyu Wan, Yuji Sun, Xuanrong Sun +1 · 1 voice
Biochemistry, Genetics and Molecular Biology · Materials Science · #Advanced biosensing and bioanalysis techniques #Nanoparticle-Based Drug Delivery #RNA Interference and Gene Delivery

paper · pdf · doi:10.1039/d4py00206g

openalex publication_date 2024/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/23

Abstract

This review introduces the basic design principles and recent advances in polymeric mRNA therapeutics, highlighting strategies to realize cancer-selective, organ-targeted, and tissue-penetrating mRNA delivery.

Citations

• The entry of nanoparticles into solid tumours
• Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing
• An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma
• Side-effect management of chimeric antigen receptor (CAR) T-cell therapy
• Advances in the development of personalized neoantigen-based therapeutic cancer vaccines
• Antigen presentation in cancer: insights into tumour immunogenicity and immune evasion
• mRNA vaccines for infectious diseases: principles, delivery and clinical translation
• High-risk human papillomavirus-18 uses an mRNA sequence to synthesize oncoprotein E6 in tumors
• Drug delivery to the central nervous system
• Therapeutic cancer vaccines

Discussions

• From our collection Polymers for Gene Delivery read "Rational design of polymer-based mRNA delivery systems for cancer treatment" by one of our Guest Editors Zhuxian Zhou et al. ⬇️ doi.org/10.1039/D4P [bsky, 0 points, 0 comments]