mRNA vaccines for infectious diseases: principles, delivery and clinical translation

2021/08/25 by Namit Chaudhary, Drew Weissman, Kathryn A. Whitehead · 19 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #RNA Interference and Gene Delivery #SARS-CoV-2 and COVID-19 Research #Viral gastroenteritis research and epidemiology

paper · pdf · doi:10.1038/s41573-021-00283-5

crossref issued 2021/08/25 · crossref published 2021/08/25 · crossref published-online 2021/08/25 · openalex publication_date 2021/08/25 · crossref created 2021/08/25 · crossref published-print 2021/11/01 · crossref deposited 2023/02/06 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30 · crossref indexed 2026/07/30

Citations

• Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures
• A new coronavirus associated with human respiratory disease in China
• Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
• Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
• Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing
• The trinity of COVID-19: immunity, inflammation and intervention
• Cell entry mechanisms of SARS-CoV-2
• An mRNA Vaccine against SARS-CoV-2 — Preliminary Report
• A global survey of potential acceptance of a COVID-19 vaccine
• Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
• Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine
• COVID-19 Vaccine Hesitancy Worldwide: A Concise Systematic Review of Vaccine Acceptance Rates
• Nanotechnology approaches for global infectious diseases
• SARS-CoV-2 variants, spike mutations and immune escape

Cited by

• N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting
• In vivo reprogramming of cytotoxic effector CD8 T cells via fractalkine-conjugated mRNA-LNPs
• The Emergence and Evolution of SARS-CoV-2
• Vaccination with mRNA-encoded membrane-bound HIV Envelope trimer induces neutralizing antibodies in animal models
• Neoantigens: promising targets for cancer therapy
• Harnessing the Potential of <scp>mRNA</scp> Vaccines Against Infectious Diseases
• Post-Transcriptional Modular Synthetic Receptors
• RNAGenScape: Property-guided Optimization and Interpolation of mRNA Sequences with Manifold Langevin Dynamics
• Virus-inspired functional spherical biomaterials constructed from high-symmetry biomacromolecules: design and applications
• Prodrug-tethered lipid nanoparticles for synergistic messenger RNA cancer immunotherapy
• mRNA vaccination facilitates the prevention and control of infectious diseases at an unprecedented speed
• Immunization with mRNA-LNPs Encoding Ornithodoros Argasid Tick Antigens Induces Humoral Immune Responses and Tick Resistance
• Insights into vaccines for elderly individuals: from the impacts of immunosenescence to delivery strategies
• A roadmap for exploring the untouched protein space for biology and medicine
• Visualizing lipid nanoparticle trafficking for mRNA vaccine delivery in non-human primates
• Global vaccine development
• Polymeric Nanoparticles for Drug Delivery
• Environment‐Responsive Peptide Dimers Bind and Stabilize Double‐Stranded RNA
• Next-Generation Vaccines against COVID-19 Variants: Beyond the Spike Protein