An artificial biocatalytic cascade for the synthesis of aryl l - threo -β-hydroxy-α-aminobutyric acids via a carbon-chain extension strategy

2025/01/01 by Sisi Zhang, Xi Chen, Mengyao Chen +7 · 1 voice
Biochemistry, Genetics and Molecular Biology · #Chemical Synthesis and Analysis #Enzyme Catalysis and Immobilization #Microbial Metabolic Engineering and Bioproduction

paper · doi:10.1039/d4gc06301e

openalex publication_date 2025/01/01 · openalex created_date 2025/02/13 · openalex updated_date 2026/08/01

Abstract

An artificial biocatalytic cascade was developed to synthesize chiral aryl β-hydroxy-α-aminobutyric acid analogues from achiral benzaldehyde derivatives, glycine, and l -threonine.

Discussions

• ❇𝐀𝐧 𝐚𝐫𝐭𝐢𝐟𝐢𝐜𝐢𝐚𝐥 𝐛𝐢𝐨𝐜𝐚𝐭𝐚𝐥𝐲𝐭𝐢𝐜 𝐜𝐚𝐬𝐜𝐚𝐝𝐞 𝐟𝐨𝐫 𝐭𝐡𝐞 𝐬𝐲𝐧𝐭𝐡𝐞𝐬𝐢𝐬 𝐨𝐟 𝐚𝐫𝐲𝐥 𝐥-𝐭𝐡𝐫𝐞𝐨-β-𝐡𝐲𝐝𝐫𝐨𝐱𝐲-α-𝐚𝐦𝐢𝐧𝐨𝐛𝐮𝐭𝐲𝐫𝐢𝐜 𝐚𝐜𝐢𝐝𝐬 𝐯𝐢𝐚 𝐚 𝐜𝐚𝐫� [bsky, 0 points, 1 comments]

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