Recent advances in the halogenated spirooxindoles as novel anticancer scaffolds: chemistry and bioactivity approach

2025/01/01 by Mohamed S. Nafie, Ihab Shawish, Sherif Ashraf Fahmy +6 · 1 voice
Chemistry · #Catalytic C–H Functionalization Methods #Synthesis and Biological Evaluation #Synthesis and Catalytic Reactions

paper · pdf · doi:10.1039/d5ra03404c

openalex publication_date 2025/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

: halogenated spirooxindoles represent a strategic advance in the development of targeted cancer therapy, combining structural ingenuity with mechanistic precision. These findings encourage medicinal chemists to optimize further halogen placement, scaffold rigidity, and hybrid designs that could lead to new target-oriented chemotherapeutics.

Citations

• Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
• Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance

Discussions

• Alhamdulillah! I am honored to announce the acceptance of our article in RSC Advances. 1st July, 2025. Recent advances in the halogenated spirooxindoles as novel anticancer scaffolds: chemistry and bi [bsky, 0 points, 0 comments]

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