Regulation of carcinogenesis through multiple zinc fingers in ZBTB20

2025/01/01 by Hyunyong Kim, Yunha Hwang, Jin Sung Cheong +1 · 1 voice
Biochemistry, Genetics and Molecular Biology · #Cancer-related gene regulation #Epigenetics and DNA Methylation #RNA modifications and cancer

paper · pdf · doi:10.1039/d5cb00088b

openalex publication_date 2025/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/04

Abstract

-acting elements to achieve specificity and selectivity. The balance of ZBTB20 expression can be a crucial issue for the regulation of two downstream transcription factors to maintain homeostasis.

Citations

• Central Dogma of Molecular Biology
• The Discovery of Zinc Fingers and Their Applications in Gene Regulation and Genome Manipulation
• Epidemiology of Hepatocellular Carcinoma

Discussions

• ZBTB20’s zinc fingers pack a punch 🧬Seung Jae Lee et al., show how it targets AFP & FOXO1 to regulate tumor pathways with the first biochemical proof of its DNA binding. Read the full paper here: do [bsky, 0 points, 0 comments]