Signals from the sea: the structural peculiarity of lipid A and weak immunostimulatory lipopolysaccharide from Rheinheimera japonica

2025/01/01 by Stefania De Chiara, Francesca Olmeo, Emanuela Andretta +8 · 1 voice
Immunology and Microbiology · Medicine · #Antimicrobial Peptides and Activities #Immune Response and Inflammation #Neonatal Respiratory Health Research

paper · pdf · doi:10.1039/d5cb00134j

openalex publication_date 2025/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

The structurally diverse lipid A from the marine bacterium Rheinheimera japonica KMM 9513 T displays weak TLR4 agonism but strong antagonism against pro-inflammatory E. coli LPS, serving as a basis for developing novel immunomodulatory analogues.

Citations

• Standardized protocols for differentiation of THP-1 cells to macrophages with distinct M(IFNγ+LPS), M(IL-4) and M(IL-10) phenotypes

Discussions

• From Rheinheimera japonica 🦠 — a marine LPS with unusual structure 🌊 and weak TLR4 activation, but able to antagonize E. coli LPS. Published in RSC Chemical Biology. 🔗 Read the full article: doi.or [bsky, 0 points, 0 comments]

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